Antipsychotic Dose Converter

In some instances, the most effective dose was well below the upper prescribing limits. For example, the most effective dose of oral risperidone—which is approved up to 16 mg/day—is 6.3 mg/day, according to the analysis. “Clinicians often use relatively high doses of antipsychotics in practice,” Leucht told Psychiatric News.

https://psychnews.psychiatryonline.org/doi/10.1176/appi.pn.2020.1b3

3 LONG-ACTING INJECTABLE ANTIPSYCHOTIC MEDICATIONS AND CONVERSION DOSING Dosing Parameters Recommended dosing of FLUPHENAZINE DECANOATE based on oral dose Daily Oral Dose of Fluphenazine Dose of Fluphenazine Decanoate every three weeks 10 mg/day 12.5 mg/3 weeks Recommended dosing of HALOPERIDOL DECANOATE based on oral dose

https://www.ceconcepts.com/sites/default/files/LAI%20Practical%20Tips%20for%20Practice.pdf

To convert patient from a different antipsychotic to Risperdal Consta#174; 1. Administer test dose of po risperidone (to check for tolerance/hypersensitivity) 2. Titrate as above 3. Continue original po atypical antipsychotic X 3 wks then dc (manufacturer rec) -or- Continue original po atypical antipsychotic X 4 wks then dc (Sac County rec)

https://dhs.saccounty.gov/BHS/Documents/Provider-Forms/Medication-Info-Sheets/Medication%20Conversion%20Chart.pdf

General conversion formula: For each 5 mg/day oral, give 50-75 mg Decanoate every 4 weeks. Recommended available dose formulations include 50 mg/ml strength, in 3 ml multiple dose vials or 100 mg/ml strength, in 5 ml multiple dose vials. Dose reduction may be necessary for CYP450 interactions of side effect intolerance. References: 1.

https://smiadviser.org/knowledge_post/what-are-dose-conversions-from-oral-to-injectable-for-the-long-acting-injectable-lai-antipsychotic-medications-available-in-the-u-s

conversion scheme should be considered. Patients treated with a dosage of 4 mg or less oral risperidone should receive 25 mg, while patients treated with higher oral doses should be considered for the higher dose of 37.5 mg. Sufficient antipsychotic coverage should be ensured during the three-week lag

https://www.candi.nhs.uk/sites/default/files/Depot%20Antipsychotic%20Medication%20Guidelines_PHA04_February%202020_0.pdf

Background: Clinicians need to know the right antipsychotic dose for optimized treatment, and the concept of dose equivalence is important for many clinical and scientific purposes. Methods: We refined a method presented in 2003, which was based on the minimum effective doses found in fixed- dose studies. We operationalized the selection process, updated the original findings, ...

https://pubmed.ncbi.nlm.nih.gov/24493852/

Initial Dose (same no matter what the oral dose ): 234mg on Day 1, then 156mg one week later; Maintenance dose (based on daily oral dose ): 3mg=39-78mg, 6mg=117mg, 12mg=234mg; RISPERIDONE (Risperdal#174; Consta#174;): Available in 12.5, 25, 37.5, and 50mg kits. No formal conversion from oral dose . Most patients maintained on 25mg or 37.5mg q2weeks

https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_Diabetes_Guide/547011/all/Antipsychotics

Dose conversion was a feasible and efficient method to compare antipsychotic exposures between administration routes and time points. Results identified that patients initiated on regular injectable therapies and multiple administration routes received higher equivalent daily-doses than those initiated on long-acting injectables and oral therapies.

https://www.frontiersin.org/articles/10.3389/fphar.2021.709349/full

If the target dose of chlorpromazine is known, give 25% of the target dose on days 1–4, 50% on days 5–8, 75% on days 9–12, then the target dose on day 13. If the target dose is not known, be guided by the patient’s previous medication history to estimate the chlorpromazine dose .

https://www.nps.org.au/australian-prescriber/articles/antipsychotic-switching-tool

Benzodiazepine Conversion Calculator. Provides equivalents between different benzodiazepines. This calculator should be used as a reference for oral benzodiazepine conversions. Equipotent benzodiazepine doses are reported as ranges due to paucity of literature supporting exact conversions, thus reported ranges are based on expert opinion and

https://www.mdcalc.com/benzodiazepine-conversion-calculator

The MED for each antipsychotic was identified from a previous systematic review and recent dose -response meta-analysis. 3,4 The authors defined the MED as follows: aripiprazole 10 mg/day, asenapine 10 mg/day, brexpiprazole 2 mg/day, cariprazine 1.5 mg/day, clozapine 300 mg/day, haloperidol 4-4.5 mg/day, iloperidone 8-12 mg/day, lurasidone 40 mg

https://www.psychiatrictimes.com/view/getting-dose-just-right

AntiPsychotic Dose Converter . by Virtual Flashcards. Rated: All Ages. Be the first to write a review. Price: $0.99. Save up to 20% on this app and its in-app items when you purchase Amazon Coins. Learn More. Sold by: Amazon.com Services LLC. Available instantly.

https://www.amazon.com/Virtual-Flashcards-AntiPsychotic-Dose-Converter/dp/B00LWTPSJ6

Introduction. There are many reasons why it is important to have dose equivalence estimates for antipsychotic drugs. Equivalent dosing is important to guarantee fair comparisons of drugs, 1, 2 for treatment guidelines, 3 and when psychiatrists need to switch from one drug to another. Patel et al 1 discussed various approaches to define dose equivalence, but they did ...

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4960429/

3. Having determined the minimum effective daily dose for each LAI, these doses were converted to the dose equivalent to 1 mg of olanzapine pamoate. How? By simply dividing the minimum effective daily dose of that antipsychotic by 15 since for olanzapine pamoate, 15 mg per day was the minimum effective dose .

https://simpleandpractical.com/dose-equivalents-long-acting-injectable-second-generation-antipsychotics/

Some drugs do not have a linear relationship between dose and antipsychotic effect Dose frequency with depots may be important due to first pass effects For drugs with wide receptor activity conversion tables are inappropriate, as they may result in increased side effects and over-sedation Differences in half-lives may complicate calculation

https://www.psychdb.com/_media/meds/antipsychotics/nhs_guidelines_antipsychotic_switch.pdf

Dose equivalents for second-generation antipsychotics : the minimum effective dose method. Schizophrenia Bulletin. 2014;40 (2):314-26. DOI: 10.1093/schbul/sbu001. PubMed PMID: 24493852; PubMed Central PMCID: PMC3932104. Leucht S, Samara M, Heres S, et al. Dose equivalents for second-generation antipsychotic drugs: the classical mean dose method

https://cpnp.org/guideline/essentials/antipsychotic-dose-equivalents

-If I.M administration every 2 weeks: Use decanoate dose equal to 4 times the total daily oral dose -If I.M. administration every 4 weeks: Use decanoate dose equal to 8 times the total daily oral dose . - Conversion from other antipsychotic depot formulations to I.M. flupentixol decanoate: Conversion ratios to calculate the equivalent dose :

https://www.just.edu.jo/DIC/AZLibrary/Flupenthixol.pdf

will be dependent on the dose , frequency and the individual’s tolerance. 3.2 As with oral antipsychotics , patients receiving LAAIs should be maintained under regular clinical review, particularly in relation to the risks and benefits of the drug regimen. Whilst in secondary care the clinician responsible will be a consultant

https://www.sussexpartnership.nhs.uk/sites/default/files/documents/laai_guidelines_-_v5_-_0118_0.pdf

Psychopharmacopeia.com is a progressive web application aimed at providing clinicians with fast access to psychiatric drug information. Quickly find indications (including off-label), dosing, side effects, clinically useful pharmacokinetic and pharmacodynamic information, drug-drug interactions, and prescribing pearls for special populations i

https://psychopharmacopeia.com/

lent dose of 59 antipsychotic preparations, including 36 orally administered agents and 13 short-acting and 10 long-acting injected agents. Clinical scenarios used olanzapine, 20 mg/ day, as the reference treatment for the equivalency estimates of the oral and long-acting injectable agents.

https://ajp.psychiatryonline.org/doi/pdf/10.1176/appi.ajp.2009.09060802

Dosage Forms 39 mg, 78 mg, 117 mg, 156 mg, and 235 mg pre-filled syringe • Schizophrenia • Schizoaffective Disorder as Monotherapy or Adjunctive therapy Initiation (2 doses) Day 1: 234 mg IM x1 dose Day 8: 156 mg IM x1 dose OR Timing of Missed Doseif CrCl ≥50 to lt;80 mL/min, 117 mg IM x1 dose *2nd initiation dose may be given between any

https://digital.sandiego.edu/cgi/viewcontent.cgi?filename=0&article=1104&context=dnp&type=additional

As different antipsychotics have different potencies, the task is more complicated than using each medication’s daily dosage in milligrams, for example. chlorpromazineR is an R package to calculate dose equivalents for common oral and injectable antipsychotic medications based on conversion factors from the published literature.

https://github.com/ropensci/chlorpromazineR

POMH-UK has created an easy to use dose converter which can aid calculation: Antipsychotic Equivalent doses4 Range of values4 Maximum dose2 FGAs – oral Chlorpromazine 100mg/day - 1000mg/day Flupentixol 3mg/day 2-3mg/day 18mg/day Fluphenazine 2mg/day 2-5mg/day 20mg/day Haloperidol 3mg/day 1.5-5mg/day 30mg/day (see BNF)

https://eput.nhs.uk/wp-content/uploads/2015/12/Section-2-Treatment-of-Psychosis-updated-Dec-2015.pdf

ANTIPSYCHOTIC DOSAGE READY RECKONER - VERSION 6.1 IM/Inhaled: dose in mg/day 5 10 15 20 25 30 33 40 45 50% 55 60 67 70 75 80 85 90 95 100% Flupentixol Depot 20 40 60 100 200 300 400 Fluphenazine Depot 12.5 25 37.5 50 Haloperidol Depot 25 37.5 50 75 Pipotiazine

https://www.cntw.nhs.uk/content/uploads/2018/09/PPT-PGN-10-App1-Ready-Reckoner-V06.1-BNF-1.pdf

Fortunately, many authors, such as Woods 2 and Davis, 3 have codified the dosing ratio equivalences of FGAs and second-generation antipsychotics (SGAs) using CPZ, 100 mg. To help psychiatrists use CPZ dosages as a point of comparison for prescribing other antipsychotics , the Table1,2,4 ( page 14) lists dose equivalents for oral FGAs and SGAs

https://www.mdedge.com/psychiatry/article/237881/schizophrenia-other-psychotic-disorders/switching-antipsychotics-guide

A dose -year is defined as the product of the dose of a particular antipsychotic (converted into equivalents of a “standard” medication such as chlorpromazine or haloperidol) and the time on that dose expressed in years. permitting us to calculate regression coefficients and create formulas that could be used to convert specific drug

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3677042/

dose in oral haloperidol equivalents should be considered for initial conversion , with downward titration on succeeding injections. •The initial dose of haloperidol decanoate should not exceed 100mg regardless of previous antipsychotic dose requirements. If conversion requires more than 100mg of haloperidol as an initial dose , that dose

https://www.thenationalcouncil.org/wp-content/uploads/2018/02/LAI-Dosing-and-Kinetics.pdf

oral dose : earlier and more rapid-ly if EPS or other side-effects. Q4 week dosing, lower cost, lower metabolic risk, clear: oral dose conversion . Less metabolic : syndrome risk than second generation anti-psychotics . Lower cost. Risk of: TD, EPS, NMS* Selected Long-acting Antipsychotic Medications: Paliper-idone Palmitate (Sustenna) Admin

https://www.thenationalcouncil.org/wp-content/uploads/2019/06/GuideToLAMs_Table-1.pdf

Recommended starting and maintenance dose of ABILIFY MAINTENA is 400 mg once monthly 1. For patients without a history of aripiprazole use, establish tolerability for up to 2 weeks with oral aripiprazole prior to initiating therapy. * Oral aripiprazole ( 10 mg ...

https://www.abilifymaintenahcp.com/schizophrenia/dosing

Antipsychotic Daily Oral Dose Range per day Depot/LAI dose Depot/LAI Range Flupentixol 2.5 mg 2-3mg 10mg / week 8-20mg / week Haloperidol 2.5 mg 1-5mg 15mg / week 5-25mg / week Zuclopenthixol 25mg 25-60mg 100mg / week 40-100mg / week Aripiprazole 15mg 10-20mg 400mg / month Risperidone 2mg 0.5-3mg 25mg / 2 weeks

https://www.rpharms.com/Portals/0/RPS%20document%20library/Open%20access/Coronavirus/Managing%20Depots%20and%20LAIs%20During%20COVID-19%20-%20CMHP%20and%20RPS%20Endorsed.pdf?ver=2020-05-01-163514-263

As different antipsychotics have different potencies, the task is more complicated than using each medication’s daily dosage in milligrams, for example. chlorpromazineR is an R package to calculate dose equivalents for common oral and injectable antipsychotic medications based on conversion factors from the published literature. We do not

https://docs.ropensci.org/chlorpromazineR/

View updated tool. The risperidone depot switches to aripiprazole and flupentixol have been updated to include recommendations to start at 25% of the target dose if starting within 3 weeks of the last injection of risperidone. All risperidone depot switches, except the switch to paliperidone, include extra clarification for this recommendation.

https://www.nps.org.au/australian-prescriber/articles/antipsychotic-switching-tool-update1

Generic 4Brand Dosage Range1 Sedation Ortho2 EPS3 Effects Equivalence5 ANTIPSYCHOTICS ANTI-ANXIETY BENZODIAZEPINES diazepam Valium 2-10 mg 5 mg chlordiazepoxide Librium 10-50 mg 25 mg clorazepate Tranxene 3.75-15 mg 10 mg clonazepam Klonopin 0.5-2.0 mg 0.25 mg lorazepam Ativan 0.5-2.0 mg 1 mg

https://www.continuingedcourses.net/active/courses/images/course015-quickreference2014.pdf

Citation: Northwood K, Theodoros T, Wang N, et al. High- dose antipsychotic therapy and reflective prescribing: development of an online tool for rapid, easy calculation of antipsychotic total daily dose . Australasian Psychiatry 2020: 1039856220917080.

https://kornor.github.io/

Dose Response and Dose Equivalence of Antipsychotics John M. Davis, MD,*y and Nancy Chen, MS*y Abstract: Wereviewevidencefromrandomized,placebo-controlled studies of patients with schizophrenia or schizoaffective disorder, which compared 2 or more doses of an antipsychotic to calculate the

https://www.rima.org/web/medline_pdf/J_Clin_Psychopharmacol_192.pdf

to Depot Conversion The decision to convert a patient from oral to LAI antipsychotics is based on 2 considerations: patient convenience or poor oral adherence. In either case, choosing the appropriate LAI dose is best accomplished by understanding the current extent of medication exposure. The prescribed oral dose is a poor indicator of

http://cdn.neiglobal.com/content/cnsspectrums/cnscme/2017/17cns01_antipsychotics.pdf

Dose titration: With respect to dosing strategies in adults with schizophrenia, a typical initial dose is 1.0- 2.0 mg/day, with a target dose of 4.0-6.0 mg/day and a maximum dose of 16.0 mg/day. The FDA approved maximum dose is 16 mg. Risperidone reaches 70 to 80 percent of D2 occupancy at doses between 2 to 4 mg/day 13,32 .

https://www.mentalhealthjournal.org/articles/fine-tuning-the-use-of-second-generation-antipsychotics.html

The initial dose of haloperidol decanoate, USP should not exceed 100 mg regardless of previous antipsychotic dose requirements. If, therefore, conversion requires more than 100 mg of haloperidol decanoate, USP as an initial dose , that dose should be administered in two injections, i.e. a maximum of 100 mg initially followed by the balance in 3

https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=f2bff27f-929f-4f7d-b3eb-084ebc2a885f

The Antipsychotic Algorithms for treatment of Schizophrenia Medication Dosing Table ATYPICAL Atypical First Dose Titration Range Schedule clozapine 12.5 mg. (#189; a 25 mg tab) Starting Day 3, dose is increased every 3 days gt; Day 2: 25 mg hs Day 3: 25 mg bid Day 6: 25 mg am 50 mg hs Day 9: 50 mg bid Day 12: 75 mg bid Day 15: 100 mg bid Day 18: 125

https://www.universityhealthsystem.com/~/media/files/clinical-pathways/11antipsychotic-medication-dosing-and-side-effects-tables.pdf?la=en

switching strategies for various antipsychotics is included here. Typical Antipsychotics Typical Oral Antipsychotics Chlorpromazine dose equivalents can be used to determine an equivalent dose for switching between typical antipsychotics (5). When switching from a low potency antipsychotic to high potency antipsychotic , the first drug should

https://ww2.health.wa.gov.au/~/media/Files/Corporate/general%20documents/WATAG/WAPDC/Antipsychotic-switching-why-how-when-March-2006.pdf

†The 234 mg INVEGA SUSTENNA #174; strength was used in the pivotal clinical trial for INVEGA TRINZA #174; as an initiation dose for patients who were being transitioned from another LAT antipsychotic . Some patients may benefit from lower initiation doses within the available strengths (39 mg, 78 mg, 117 mg, and 156 mg).

https://www.invegasustennahcp.com/dosing/transitioning

Long-Acting Antipsychotics Dose Conversion . Dr. Harvinder Singh October 26, 2019. Dr. Harvinder Singh, MD. Admin, Psychiatry Education Forum. Facebook Twitter Instagram Youtube Linkedin. Physician’s Guide for Clinical Psychiatry Course Subscribers will have more detailed access to following chapters in

https://psychiatryeducationforum.com/antipsychotics-dose-conversion-chart/

We convert all antipsychotic doses to chlorpromazine equivalents, using published equivalencies for oral conventional (American Psychiatric Association 1997) and atypical (Woods 2003) antipsychotics . For depot haloperidol, fluphenazine, and risperidone, we use the manufacturers’ recommended equivalent for the depot to oral conversion for the

http://scottwilliamwoods.com/files/Equivtext.doc

-If I.M administration every 2 weeks: Use decanoate dose equal to 4 times the total daily oral dose -If I.M. administration every 4 weeks: Use decanoate dose equal to 8 times the total daily oral dose . - Conversion from other antipsychotic depot formulations to I.M. flupentixol decanoate: Conversion ratios to calculate the equivalent dose :

https://www.just.edu.jo/DIC/AZLibrary/Flupenthixol.pdf

dose in oral haloperidol equivalents should be considered for initial conversion , with downward titration on succeeding injections. •The initial dose of haloperidol decanoate should not exceed 100mg regardless of previous antipsychotic dose requirements. If conversion requires more than 100mg of haloperidol as an initial dose , that dose

https://www.thenationalcouncil.org/wp-content/uploads/2018/02/LAI-Dosing-and-Kinetics.pdf